MyDogDNA canine testing service discovers known gene for canine bleeding disorder also in Finnish Hound and Welsh Springer Spaniels


Genoscoper Laboratories, genomics laboratory in Helsinki, Finland, reports today that they have identified the known mutation responsible for a canine bleeding disorder called Canine Factor VII Deficiency (cFVII) in two dog breeds, the Finnish Hound and the Welsh Springer Spaniel. The discovery has been made with MyDogDNA, canine DNA testing service based on a dog’s genome-wide analysis.


Canine Factor VII Deficiency is caused by a mutation in the Factor VII gene, which encodes a protein that is crucial for the initiation of blood coagulation. It is inherited as an autosomal recessive gene, so a dog needs to inherit the defective gene from both its sire and dam to manifest the disease. Symptoms of Canine Factor VII Deficiency can include bruising, bleeding from the nose or vagina, or internal bleeding, but the disorder typically goes unnoticed until trauma or surgery results in prolonged bleeding affected dogs. Clinical symptoms can be reduced by blood transfusions or recombinant FVII therapy, but long-term management is difficult.


The mutation was originally discovered in Beagles and has since been reported in the Airedale Terrier, Alaskan Klee Kai, Giant Schnauzer, and Scottish Deerhound. Because the consequences of a genetic mutation are not necessarily the same in every breed, the discovery of cFVII in these two additional breeds highlights the need for further research to validate the link between the mutation and its manifestation as the bleeding disorder. As the next step, the MyDogDNA research team, headed by Dr. Jonas Donner at Genoscoper Laboratories, will be cooperating with other researchers, breed clubs, breeders, and veterinarians worldwide to identify genetically affected (homozygous) dogs and determine if this mutation indeed produces the same bleeding disorder seen in other breeds.


Breakthrough technology will improve canine health

The Finnish-based Genoscoper Laboratories is the first canine diagnostics laboratory in the world to use a genome-wide DNA analysis for genetic testing.  Unlike single-gene tests, MyDogDNA's comprehensive panel analysis tests for over hundred known mutations simultaneously, using only a single DNA sample swabbed from inside the dog's cheek.  The technology also records at the same time thousands of neutral chromosomal markers that can be used to measure genetic diversity and even locate new mutations associated with other genetic disorders. 


The development of comprehensive panel screening allows MyDogDNA to provide much deeper insights into canine genome.  This will translate into genetic information that can be used by breeders and veterinarians to reduce the incidence of inherited diseases in dogs. 



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About MyDogDNA
MyDogDNA™ testing services provided by Genoscoper Laboratories help explore inherited characteristics in dogs. The world's first genome-wide DNA analysis, core of the MyDogDNA testing services, enables panel screening of several known canine hereditary disorders and conformational traits with a comprehensive assessment of the level of inbreeding of a single dog as well as that of the breed. The global MyDogDNA database provides dog breeders with information and new tools to reduce harmful inbreeding and disease load within their breed.